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Beilstein J. Org. Chem. 2015, 11, 1352–1359, doi:10.3762/bjoc.11.145
Graphical Abstract
Scheme 1: Chemical structures of the conjugates (nucleobase–amino acids–saccharide (NAS)), and nucleopeptides...
Scheme 2: The representative synthesis route of conjugates NAS (1, including solid-phase peptide synthesis an...
Figure 1: TEM images of (A) solution of 1 + 8; (B) hydrogel of 5 + 8; (C) solution of 7 + 8. Each component i...
Figure 2: (A) Strain sweep and (B) frequency sweep of the solution of 1 + 8, the hydrogel of 5 + 8, and the s...
Figure 3: Compounds remained after incubating with proteinase K (3.2 U/mL) for 24 h at 37 °C. (A) Each conjug...
Figure 4: Cell viability of HeLa cells incubated with (A) 1, (B) 2, (C) 3, (D) 4, (E) 5, (F) 6, (G) 7, (H) 8 ...
Figure 5: Cell viability of PC12 cells incubated with (A) 1, (B) 2, (C) 3, (D) 4, (E) 5, (F) 6, (G) 7, (H) 8 ...
Figure 6: Cell viability of (A) HeLa and (B) PC12 cells incubated with 5 + 8 at different concentrations.